Victoria Goldenshtein

PhD Candidate in Biomedical Engineering at Duke University

An analytical chemist by training, my undergraduate research involved examining the affinity of zinc finger proteins to heavy metals. My interest in targeted drug delivery developed during my work in a clinical stem cell lab at the NY Blood Center, where we focused on the isolation of CD34+ cells from Hematopoietic Progenitor Cells of apheresis products. While pursuing my masters degree, I joined the Mathiowitz lab at Brown University, where I learned techniques of polymeric nanoencapsulation and investigated factors affecting interaction of nanoparticles with gastrointestinal mucin for the purpose of developing novel oral drug delivery systems.

My interest in the Tadross lab stemmed from a deep fascination with the DART method—specifically, its ability to provide cell-type and molecular specificity, and its potential to revolutionize pharmacological applications. The objective of my Ph.D. at Duke University is to optimize the efficiency of DART for non-invasive systemic delivery of genetically targeted therapeutics and multiplexed drug delivery. To do so, I developed a novel directed protein evolution technology – GRIP Display – under the mentorship and guidance of prof. Tadross. This approach allows simultaneous screening of a large number of protein variants (10^14), yielding optimal variants in a short timeframe.

Outside of lab, I spend most of my free time with my kids, and I love to travel. So far, I’ve resided in three countries, speak four languages, and am always willing to learn more!

Contact Information

Education

  • BS in Chemistry, minor in Biochemistry, CUNY, 2011

  • MSc in BME, Brown University, 2017

  • Sr. Lab Assistant at Stem Cell lab, NY Blood Center, 2011-2013

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