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THE

TADROSS LAB

at Duke University

engineers and neuroscientists working together to solve the brain

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ABOUT US

ABOUT US

DART

Dynamics

Disease

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Our lab develops tools to empower the neuroscience community. We believe that tools should be as simple as possible, while addressing broad conceptual questions. 

For example, DART (Drugs Acutely Restricted by Tethering)  makes it possible to deliver traditional drugs to defined cell types in a behaving animal. There are  two steps:

(1) first, a virus is used to select the cells of interest.

(2) weeks later, any drug from of our catalog can be delivered exclusively to these cells, with no effect on neighboring cells.

As with traditional pharmacology, DART involves no overexpression of the receptor of interest, and drug effects have acute onset. Unlike traditional pharmacology, DART is cell type-specific. This makes it possible to map "drug x cell-type" effects on behavior, without caveats of overexpression or compensatory artifacts.

We keep making DART better.  Our priorities are to expand the available drug catalog, and to make the tool even easier to use via whole-brain non-invasive dosing. If you have an interest in DART, we collaborate extensively, and are eager to help. 

CoverConcept_verOrig.jpg

Our lab develops tools to empower the neuroscience community. We think tools should be simple, while addressing broad conceptual questions. 

For example, DART (drug acutely restricted by tethering)  makes it possible to deliver pharmaceuticals to defined cells of a behaving animalin two steps:

  1. first, a virus is used to select the cells of interest.

  2. weeks later, any drug in our catalog can be delivered to these cells, with no effect on neighboring cells.

Like traditional pharmacology, DART has acute onset and involves no receptor overexpression.  DART is also cell type-specific.  These features are unique, making it possible to map "drug x cell-type" effects on behavior, without overexpression or compensatory artifacts.

We keep making DART better, and are expanding the drug catalog. If you have an interest in DART, we collaborate extensively, and are eager to help. 

News

NEWS

A Reason to Celebrate

May 10, 2024

Congratulations to the new PhD graduate, Aki Min!

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PEOPLE

CURRENT MEMBERS

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Assistant Professor

Biomedical Engineering & Neurobiology

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Research Associate

Biomedical Engineering

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Senior Research Scientist

Biomedical

Engineering

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PhD, Biomedical Engineering

Postdoctoral Associate

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MD/PhD Candidate

Biomedical Engineering

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PhD, Psychology & Neuroscience

Postdoctoral Associate

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PhD Candidate

Neurobiology

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PhD Candidate

Biomedical Engineering

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PhD Candidate

Biomedical Engineering

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PhD Candidate

Neurobiology

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PhD Candidate

Biomedical Engineering

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PhD Candidate

Biomedical Engineering

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Research Resident

Psychiatry

Alumni

GRADUATES & ALUMNI

June 2024, S. Aryana Yousefzadeh ― PhD in Psychology & Neuroscience → Postdoc

May 2024, Akira Min ― PhD in Neurobiology → Technology Marketing Associate, Duke OTC

June 2023, Sasha Burwell ― PhD in Neurobiology → Integrated Product Development Associate, Rho Inc.

May 2023, Ankit Choudhury ― Tech II → Univ. of Wisconsin Medical School

Mar. 2023, Victoria Goldenshtein ― PhD in Biomedical Engineering → Postdoc & Entrepreneur

Feb. 2023, Kyle Jensen ― Postdoctoral Associate → Sophion & ExstoBio  

Oct. 2022, Isaac Weaver ― PhD in Biomedical Engineering → Senior Associate, Jefferies

May 2022, Austin Li ― BS in Biomedical Engineering → Case Western Medical School

Mar. 2021, Elizabeth Kahuno ―  Associate in Research → U. Mass. Med. School / Melikian Lab

Aug. 2018, Jane Tandler ―  Masters in Neurobiology → Development Director, StepUp Durham

PUBLICATIONS

Contact Us

Duke University

Pratt School of Engineering

Bryan Research Building

311 Research Drive, Room 331

Durham, NC, 27710

(919) 681-6739

CONTACT US
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