THE

TADROSS LAB

at Duke University

engineers and neuroscientists working together to solve the brain

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ABOUT US

DART

Dynamics

Disease

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Our lab develops tools to empower the neuroscience community. We believe that tools should be as simple as possible, while addressing broad conceptual questions. 

For example, DART (Drugs Acutely Restricted by Tethering)  makes it possible to deliver traditional drugs to defined cell types in a behaving animal. There are  two steps:

(1) first, a virus is used to select the cells of interest.

(2) weeks later, any drug from of our catalog can be delivered exclusively to these cells, with no effect on neighboring cells.

As with traditional pharmacology, DART involves no overexpression of the receptor of interest, and drug effects have acute onset. Unlike traditional pharmacology, DART is cell type-specific. This makes it possible to map "drug x cell-type" effects on behavior, without caveats of overexpression or compensatory artifacts.

We keep making DART better.  Our priorities are to expand the available drug catalog, and to make the tool even easier to use via whole-brain non-invasive dosing. If you have an interest in DART, we collaborate extensively, and are eager to help. 

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Our lab develops tools to empower the neuroscience community. We think tools should be simple, while addressing broad conceptual questions. 

For example, DART (drugs acutely restricted by tethering)  makes it possible to deliver pharmaceuticals to defined cells of a behaving animalin two steps:

  1. first, a virus is used to select the cells of interest.

  2. weeks later, any drug in our catalog can be delivered to these cells, with no effect on neighboring cells.

Like traditional pharmacology, DART has acute onset and involves no receptor overexpression.  DART is also cell type-specific.  These features are unique, making it possible to map "drug x cell-type" effects on behavior, without overexpression or compensatory artifacts.

We keep making DART better, and are expanding the drug catalog. If you have an interest in DART, we collaborate extensively, and are eager to help. 

NEWS

Enjoying The Triangle

Nov 2, 2021

Celebrating our lab, enjoying Namu's amazing outdoor venue.

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CURRENT MEMBERS

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Austin Li

Associate in Research

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Research Technician II

ALUMNI

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Masters in Neurobiology

Jane Tandler

 
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Assistant Professor of Biomedical Engineering

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Research Associate

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MD/PhD Candidate in Biomedical Engineering

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PhD Candidate in Biomedical Engineering

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PhD Candidate in Biomedical Engineering

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PhD Candidate in Neurobiology

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PhD Candidate in Neurobiology

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PhD Candidate in Neurobiology

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PhD Student in Biomedical Engineering

 
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PhD Candidate in the Systems and Integrative Neuroscience program

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Senior Research Scientist (joint with the Greg Field lab)

FEATURED PUBLICATIONS

Shields BC*, Kahuno EW*, Kim C*, Apostolides PF*, Brown J, Lindo S, Mensh BD, Dudman JT, Lavis LD, Tadross MR‡. "Deconstructing behavioral neuropharmacology with cellular specificity.Science 356, no. 6333 (2017).

Manz KM, Coleman BC, Grueter CA, Shields BC, Tadross MR, Grueter BA. "Noradrenergic signaling disengages feedforward transmission in the nucleus accumbens shell.Journal of Neuroscience JN-RM-2420-20 (2021).

Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, Gallinger IM, Xiang Z, Branthwaite H, Melugin PR, Williford KM, Centanni SW, Shields BC, Lindsley CW, Calipari ES, Siciliano, CA, Niswender CM, Tadross MR, Winder DG, Conn PJ. "Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons.Neuron (in press, 2022).

Click here to see our full list of publications

 

Contact Us

Duke University

Pratt School of Engineering

Bryan Research Building

311 Research Drive, Room 331

Durham, NC, 27710

(919) 681-6739